Simple operation
Molecular-level testing that does not require specialist staff. A two-step workflow: extract, then amplify and read.
RAA · Recombinase-Aided Amplification
Nucleic acid detection at a constant 37–42 °C, read in 5–15 minutes.
ZC Bioscience develops RAA isothermal amplification reagents, rapid extraction kits and the portable Genchek fluorescence analyzer — so molecular testing can leave the thermal cycler behind and travel to the sample.
All reagents are for research use only. Not for use in diagnostic procedures.
Lyophilised · 8-strip
No thermal cycler
Add Buffer A + B + template
Real-time fluorescence or strip readout
5–15 minTime to a fluorescence result
30–42 °CIsothermal reaction; optimum 37–39 °C
1 % (w/w)Limit of detection, meat-species kits
103 cfu/mLLimit of detection, pathogen kits
RAA Technology
An isothermal alternative to PCR, built on three proteins.
Recombinase-Aided Amplification (RAA) is a rapid isothermal nucleic acid amplification technology. A recombinase obtained from bacteria or fungi binds tightly to the primer DNA at ambient temperature, forming a recombinase–primer complex. When the primer locates its fully complementary sequence on the template, single-stranded DNA-binding protein helps open the double strand, and DNA polymerase synthesises a new complementary strand. The product accumulates exponentially.
With a labelled fluorescent probe the reaction can be read in real time; a fluorescence result is typically available within 5–15 minutes. All reaction components are pre-mixed and lyophilised in the tube — add Buffer A, Buffer B and the extracted sample DNA. RAA can in principle be multiplexed: two or more primer pairs in one reaction amplify several targets simultaneously.
Fast
Results in 5–15 minutes with a fluorescent probe; truly rapid testing for high-volume sample streams.
Accurate
High sensitivity and specificity — the recombinase–primer complex recognises the target sequence by base pairing.
Portable
Compact instruments suited to harsh field conditions and on-site inspection, with battery operation on the Genchek analyzer.
Isothermal
Runs at 30–42 °C. No thermal cycler or other expensive equipment is required — a heat block or water bath is enough for gel readout.
Lyophilised
Reagents supplied as freeze-dried pellets: ready to use, easy to ship, and free from freeze–thaw loss and pipetting error.
Platform comparison
RAA vs PCR vs LAMP
Where isothermal recombinase-driven amplification sits against the two methods most laboratories already run.
| Parameter | ● RAA | PCR | LAMP |
|---|---|---|---|
| Enzymes | Recombinase, SSB, strand-displacing DNA polymerase | Taq DNA polymerase | Strand-displacing DNA polymerase |
| Reaction temperature | 37–39 °C, constant | High temperature, thermal cycling | 60–65 °C, constant |
| Reaction time | 15 min | 1.5 h | 40 min |
| Primer pairs | 1 | 1 | 2 |
| Reagent format | Lyophilised pellet | Liquid | Liquid |
| Readout | Gel; real-time fluorescence; lateral-flow strip | Gel; real-time fluorescence | Visual turbidity |
| Noted drawback | — | Slow | Aerosol carry-over, false positives |
Products · 29 items in 5 categories
Reagents, extraction kits and instruments for one RAA workflow.
Every reagent below is for research use only (RUO). Pricing is by quotation — tell us your targets and volumes.
RAA Core Amplification Kits (RUO)
Six enzyme kits for your own primers and probes.
Open RAA chemistry for laboratories developing their own assays. All components are pre-mixed and lyophilised; primers should be 30–35 bp and probes 46–52 bp for optimal performance. Fluorescent kits use a probe cleaved by exonuclease for real-time readout; RT kits reverse-transcribe RNA first.
- 48 tests per kit, 50 µL reaction
- Over 107-fold amplification of the target
- 30 min at 30–42 °C yields a gel-detectable product
- Store at -20 °C, dry and dark; 12-month shelf life
RAA Basic Nucleic Acid Amplification Kit (RUO)
Rapid amplification of DNA at 37 °C; product confirmed by agarose gel electrophoresis. Runs on a heat block, water bath or incubator.
DNAGel readout
Request a Quote RAA Fluorescent Nucleic Acid Amplification Kit (RUO)
Rapid amplification of DNA with real-time monitoring on the Genchek analyzer or a standard real-time PCR instrument; 5–20 min.
DNAReal-time
Request a Quote RT-RAA Basic Nucleic Acid Amplification Kit (RUO)
Rapid amplification of RNA; reverse transcription then isothermal amplification at 37 °C with gel readout.
RNAGel readout
Request a Quote RT-RAA Fluorescent Nucleic Acid Amplification Kit (RUO)
Rapid amplification of RNA with real-time fluorescence readout on Genchek or qPCR instruments; 5–20 min.
RNAReal-time
Request a Quote RAA-nfo Nucleic Acid Amplification Kit, Lateral-Flow Strip (RUO)
Rapid DNA amplification at 39 °C; a dual-labelled amplicon is read on a universal nucleic acid lateral-flow strip — no instrument needed.
DNAStrip readout
Request a Quote RT-RAA-nfo Nucleic Acid Amplification Kit, Lateral-Flow Strip (RUO)
Rapid RNA amplification at 42 °C with lateral-flow strip readout; reverse transcription built in.
RNAStrip readout
Request a Quote 
Instrument
Genchek Isothermal Fluorescence Analyzer
An integrated, portable rapid-test analyzer for on-site and mobile testing. Built-in reagent mixing, fully matched to RAA reagents; dual fluorescence channels (FAM & ROX); automatic data analysis and report generation with multiple report-export options. All assays run under one software interface and results are read from a single display.
| Throughput | 8 wells × 2 channels — up to 16 targets per run |
|---|---|
| Fluorescence channels | FAM / ROX |
| Temperature range · accuracy | Ambient to 65 °C · ±0.5 °C |
| Net weight · dimensions | 3.8 kg · 255 × 240 × 123 mm |
| Power | 120 W · AC 100–240 V, 50/60 Hz |
| Operating environment | 5–35 °C, 20–80 % RH |
25+ RAA assays across animal species, foodborne pathogens and GMO elements.
Request a Quote
Rapid Nucleic Acid Extraction Kits (RUO)
RAA-ready template in 5 to 25 minutes.
Purpose-built front ends for the RAA reaction: heat-lysis, spin-column and magnetic-bead formats that yield amplification-ready DNA or RNA without hazardous solvents and with low cross-contamination risk.
- 50 preps per kit (96 for the pre-filled plate)
- Store at room temperature, dry; 12 months
- No organic extraction, no ethanol precipitation
- Sample types from meat and feed to swabs and blood
Rapid DNA Extraction Reagent, heat-lysis (RUO)
Genomic DNA in 5 minutes from animal tissue, blood, meat products, plant tissue, seeds and bacteria. A surfactant lysis mix with no protein or RNA removal steps.
Heat lysis · 5 min50 preps
Request a Quote Universal Rapid DNA Extraction Kit, spin column (RUO)
Lyse–bind–wash–elute in 15 minutes. Animal tissue, cells, bacteria, saliva, blood, swabs, faeces, bone and feed; high yield and stable quality.
Spin column · 15 min50 preps
Request a Quote Universal Rapid RNA Extraction Kit, spin column (RUO)
Four steps, 10 minutes, high-quality RNA from animal tissue, cells, saliva, blood, swabs and faeces — ready for RT-RAA.
Spin column · 10 min50 preps
Request a Quote Magnetic-Bead DNA Extraction Pre-filled Plate (RUO)
For automated magnetic-bead extractors. Nano-magnetic-bead purification of DNA from animal tissue, cells, saliva, blood and swabs in 25 minutes; cuts hands-on time for large sample batches in food safety, environmental microbiology, livestock and molecular biology research.
Magnetic beads · 25 min96 preps
Request a Quote 
Food Safety Molecular Detection Series (RUO)
Seventeen ready-to-run RAA fluorescent kits.
Target-specific kits that recognise and amplify a species- or pathogen-specific gene fragment at 30–42 °C (optimum 37–39 °C). Result read directly from the amplification curve and time — no electrophoresis.
- 24 tests per kit, lyophilised
- Store at -20 °C, protected from light; 6 months
- Genchek-I / Genchek-II or standard real-time PCR instruments (ABI, MJ, Roche, Bioer series)
- Meat-species LOD 1 % (w/w); pathogen LOD 103 cfu/mL
Animal-Derived Ingredient Molecular Detection Kits (RAA, Fluorescent) (RUO)
Species-specific kits for animal tissue, blood, foods, meat products (including processed meat) and feed. No cross-reaction observed between the listed species; different breeds of each species are detected.
ChickenDuckPorkBovineSheep & goatRatHorseMinkFoxDonkey
Request a Quote Foodborne Pathogen Molecular Detection Kits (RAA, Fluorescent) (RUO)
Qualitative detection in foods, beverages, water, cosmetics, disposable hygiene products and seafood; result in 5–15 min. Method reference: GB 4789 series and SN/T standards for each organism.
Staphylococcus aureusSalmonellaPseudomonas aeruginosaListeria monocytogenesHaemolytic StreptococcusVibrio parahaemolyticusShigella
Request a Quote GMO Screening Kits (RAA, Fluorescent) (RUO)
Element kits for the six common screening elements, plus event-specific kits for GM soybean, maize and canola lines listed in our catalog. 24 tests per kit.
BtbarhptCaMV 35SFMV 35Snos
Request a Quote
Product photograph to follow
Instrument
Genchek Fully Automated Isothermal Nucleic Acid Detection System
Fully automated, sample-in / result-out in 30 minutes. Performs quantitative pipetting, sample lysis, nucleic acid purification, isothermal amplification, fluorescence detection, analysis and reporting in one instrument — load the sample and the system does the rest.
| Run time | ~30 min, extraction and amplification integrated |
|---|---|
| Sample throughput | 1 sample per run |
| Fluorescence channels | FAM / ROX |
| Interface | 7-inch colour touchscreen |
| UV lamp · air purification | Yes · Yes |
| Weight · dimensions | 16 kg · 260 × 325 × 420 mm |
| Power | 221 W · AC 220 V, 50 Hz |
| Pipetting | <15 µL accuracy >98 %, CV <5 %; 15–50 µL >98.5 %, CV <3 %; >50 µL >99 %, CV <1.2 % |
Real-time fluorescence curves; automatic analysis and report generation.
Request a Quote
Solutions
Three food-safety questions, one 15-minute answer.
Each solution pairs target-specific RAA fluorescent kits with the Genchek analyzer, which monitors amplification in real time and completes the run in 15 minutes.
Meat species authentication
As price gaps between meats widen, species substitution and adulteration are increasingly common. RAA-based species kits detect species-specific genes, identifying meat origin at the molecular level with no cross-reaction between species.
10 speciestargets
1 % (w/w)adulteration LOD
5–15 minto result
ChickenPorkDuckBeefSheep/goatRatHorseMinkFoxDonkey
For regulators, customs and border inspection, livestock authorities, agricultural research institutes; food, dietary-supplement and feed manufacturers; third-party testing laboratories.
Foodborne pathogen detection
In China, pathogenic bacteria account for an estimated 40–50 % of reported foodborne-illness cases each year. RAA pathogen kits combine multi-channel detection, short run times and high sensitivity — raising throughput and moving food-safety warnings earlier.
9 targetsorganisms
103 cfu/mLLOD
5–15 minto result
S. aureusSalmonellaP. aeruginosaL. monocytogenesHaemolytic StreptococcusV. parahaemolyticusShigellaE. coli O157:H7V. cholerae
Qualitative detection in food, beverages, cosmetics and seafood. Method reference: GB 4789 series, SN/T. For regulators, public-health laboratories, food and cosmetics manufacturers, third-party laboratories.
GMO screening
GM crops carry genes introduced from other organisms to alter traits, nutrition or quality, and regulators worldwide require labelling and control. RAA-based GMO kits specifically detect exogenous elements and events in crops, identifying GM material at the molecular level.
6 elementsscreening
Event kitssoybean, maize, canola
5–15 minto result
BtbarhptCaMV 35S promoterFMV 35S promoternos terminator
For regulators, customs and border inspection, agricultural research institutes; food and feed manufacturers; third-party testing laboratories.
Services
Support that continues after the kit ships.
Consultation, documentation, training and after-sales support from the team that develops the chemistry — plus custom assay development for targets not yet in the catalog.
Technical support
Our R&D team answers every product question with patient explanation and demonstration. Example workflow for a species assay: weigh 50 mg sample into the extraction solution, incubate at 70 °C for 10 min; add 45.5 µL Buffer A, 2.5 µL Buffer B and 2 µL template; place in the Genchek analyzer; result in 5–15 min.
- Technical consultation
- Documentation and instructions for use
- Operator training
After-sales service
Good after-sales service earns customer trust. We provide quality after-sales support with long-term technical documentation. Our engineers respond promptly and resolve issues remotely by email, online session or phone.
- Remote troubleshooting
- Instrument support for Genchek systems
- Long-term documentation updates
Custom assay development
RAA is a versatile, portable rapid-testing platform that can replace LAMP or PCR in many workflows. We develop custom RAA assays on request and co-develop detection kits with partner organisations under strategic agreements.
- New target design and verification
- OEM reagent supply
- Multiplex RAA (two or more targets per tube)
Support hours: Monday to Friday, 9:00–18:00 (UTC+8) · +86 571 8861 9668 · zcsw2017@163.com
Discuss a custom target
Company
An R&D-driven biotechnology company in Hangzhou.
Hangzhou ZC Bio-Sci & Tech Co., Ltd. ("ZC Bioscience") develops and applies Recombinase-Aided Amplification (RAA), an isothermal nucleic acid amplification technology, and supplies RAA-based reagents, extraction kits and portable fluorescence instruments for rapid molecular testing.
Since September 2016 the company has accelerated product development for RAA-based rapid food-safety testing, launching in turn the animal-species molecular detection series, the foodborne pathogen molecular detection series and the GMO ingredient molecular detection series. ZC Bioscience has signed strategic cooperation agreements with government institutions and research organisations across several fields to co-develop RAA-based detection kits.
500 m2Laboratory space, plus 400 m² of offices
RMB 12M+Installed laboratory equipment
90 %+R&D staff holding master's degrees or higher
5050Hangzhou Binjiang District Talent Program; key enterprise cultivated by the district
Application areas
Food safety — pathogensMeat-species authenticationGMO screeningEnvironmental monitoringAquaculture pathogen detectionAnimal disease detection
News
Notes from the field.
Explainer | Recombinase-Aided Rapid Nucleic Acid Amplification
In vitro nucleic acid amplification lets trace amounts of nucleic acid be amplified rapidly and efficiently. RAA is an isothermal method built on existing amplification principles: recombinase, single-stranded DNA-binding protein and DNA polymerase replace the thermal-cycling denaturation of conventional PCR, so amplification proceeds at a constant 37 °C.
Highlights | RAA Technology Debuts at the Food Microbiology Detection & Control Exchange
On 20–22 July 2017 the 7th Food Microbiology Detection and Control Technology Exchange was held in Shanghai, jointly organised by the Agro-product Safety Research Center of the Chinese Academy of Inspection and Quarantine, the Analytical Microbiology Committee of the Chinese Society for Microbiology, and Foodmate. The meeting ran 17 themed sessions with over 30 exhibitors and 300+ laboratory professionals.
Forum | 7th Food Microbiology Detection & Control Technology Exchange, 19–22 July
Foodborne disease caused by pathogenic microorganisms is the number-one food-safety issue. Controlling contamination, strengthening laboratory capability and applying advanced microbial detection and control technology in production have become focal concerns for regulators and food companies alike. ZC Bioscience will attend and exhibit.
ZC Bioscience at the 10th China International Food Safety & Quality Conference (CBIFS 2017)
The annual CBIFS food-safety technology forum was held on 7–8 April 2017 at the Hangzhou International Expo Center. ZC Bioscience, a newcomer to food-safety testing, made its debut at the conference; on the morning of the 7th the ZC Bioscience booth drew strong visitor interest.
Ready to run RAA in your laboratory?
Send us your targets, sample types and monthly volumes. We reply with a quotation, instructions for use and compatible-instrument guidance.
Contact
Hangzhou ZC Bio-Sci & Tech Co., Ltd.
- Address
- Tianhe Hi-Tech Park, Building 5, 688 Bin'an Road, Binjiang District, Hangzhou 310052, China
- zcsw2017@163.com
- Phone
- +86 571 8861 9668
- Hours
- Monday to Friday, 9:00–18:00 (UTC+8)